Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.

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After a number of trials, microemulsion of aceclofenac was optimized with: The resultant microemulsion and emulgel both exhibited the desired drug release in-vitro and ex-vivo. Evaluation of microemulsion 4 – 7 Appearance and pH: Croton oil induced ear edema: Ex-vivo drug release of emulgel was znd to be However, these differences were not statistically significant.

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The microemulsion which had highest amount of drug solubility and water uptake in the pseudo eumlgel phase diagram was chosen for trials on microemulsion. Female wistar rats weighing g were divided into three groups.

Emulgel is one of the emerging topical drug delivery system for the delivery of hydrophobic drugs which overcome various disadvantages of ointments and creams such as greasiness and phase inversion. Group I was diseased control, group II received dose of 25 mg of aceclofenac emulgel whereas group III received marketed diclofenac emulgel.

Similar Articles in this Journal. It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus MRSA infections. Oil was mixed in the Smix for around 10 min on a magnetic evalhation. Formulation development and characterization of microemulsion drug delivery systems containing antiulcer drug.

In both the models, the inflammatory edema reached its maximum level at the frmulation and later started declining. A total of 6 rats were used in each group, for placebo, marketed gel and aceclofenac formulated emulgel, amounting to 18 rats in total. Carrageenan induced paw edema and croton ear edema model. Ointments, Creams and Gels.


The solubility of aceclofenac in different oils, surfactants and co-surfactants was determined since it is the most important criteria for microemulsion preparation Table 2. Species-dependent metabolism and newer paradigm shift from oral to non-oral delivery. In this regard, the study provides a preliminary comparative efficacy data for both the drugs, providing a foundation for a robust clinical evaluation in future studies.

The aceclofenac microemulsion was transparent yellow colored solution with a pH of 5.

Search in Google Scholar. These are applied as wide spectrum of preparations in case of both cosmetic and dermatological, to the healthy or diseased skin. Microemulsion-based media as novel drug delivery systems. The particle size and zeta potential of the microemulsion was evaluated using nano zeta sizer. Compared with ointments and creams, gelsprovide a better feel are greaseless and easily washable. Secondly, relevance of this fact is even more when the respective drugs are taken life-long in chronic conditions like arthritis.

The dialysis membrane was attached between the donor and the receptor chamber of diffusion cell.

Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice. Ex-vivo studies were done in the same manner as that of in vitro diffusion studies where the dialysis membrane was replaced with rat skin.

Invited for research articles. The inflammation in the ear of each rat was noted using Vernier caliper at 1st, 2nd, 3rd and 4th h of treatment.

Additionally, a gel formulation aids in faster drug release in comparison to other semisolids 2. Elsadig Gasoom FadelAlla Elbashir.

Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.

Hence, the formulation strategy for aceclofenac and thereby, an efficient drug delivery led to an effective anti-inflammatory activity.

Based on the results of solubility studies, Isopropyl myristate, Polysorbate 80 and Ethanol were chosen as oil, surfactant and co-surfactant, respectively. The solubilization capability of aceclofenac in different oils, surfactant and co surfactant was shown in the Table 1. The receptor chamber was stirred by magnetic stirrer. The prepared emulgels were evaluated for physical appearance, pH, drug content, In-vitro diffusion studies, microbiological assay and skin irritation test.


An effective anti-inflammatory drug is purported to act via both the pathways, thus mitigating inflammation. The formultaion was commenced after the od approvals from the concerned authorities as well as the animal ethics committee. The swelling in the paw of each rat was measured by plethysmometer by volume displacement method at baseline and every h till the 6th h Samples were analyzed for drug content by UV-Vis spectrophotometer after appropriate dilutions.

Both of these models differ in terms of underlying pathways of the inflammatory cascade. Chemate Department Of Pharmaceutics, P.

Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.

In this investigation, a microemulsion-based emulgel of aceclofenac was successfully formulated, which lead to improved solubility and drug release of aceclofenac. Microemulsion of aceclofenac was formulated with various polymers and optimized. On the contrary, in the placebo group inflammation persisted till the 4th h and later showed a decline which was statistically insignificant compared to the treated groups, which reinstates wmulgel efficacy of aceclofenac, lack of any activity attributed to excipients and effective delivery of the drug.

Film Forming Emulgels have emerged as one of the most interesting topical drug delivery systems as it has dual release control i. Formulation, development and evaluation of emulgel: How to cite this article: It combines dual release pattern of both gel and emulsion providing better therapeutic action and sustained release 34.


In another study by Shah et al. The anti-inflammatory activity of aceclofenac emulgel was evaluated using carrageenan induced paw edema in rats by a method described by Gerald et al. F1 and F2 with 0.